Koel banerjee biography sample
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Significance
The role of well-placed charges within proteins in mediating biological functions, from protein-protein association to enzyme kinetics, is well documented. Here, we go beyond this static picture and show that charge motions can exert significant effects on protein function. Injecting charge from a photosensitizer, we demonstrate a threefold decrease in enzymatic activity and a twofold increase of antibody-antigen binding. These effects depend on the specific position of the photosensitizer on the protein. Our results point to charge reorganization as a form of allostery that complements known allosteric mechanisms such as conformational changes and dynamics.
Keywords: allostery, protein-protein association, enzymatic activity, polarizability, chiral-induced spin selectivity
Abstract
Considerable electric fields are present within living cells, and the role of bioelectricity has been well established at the organismal level. Yet much remains to be learned about electric-field effects on protein function. Here, we use phototriggered charge injection from a site-specifically attached ruthenium photosensitizer to directly demonstrate the effect of dynamic charge redistribution within a protein. We find that binding of an antibody to phosphoglycerate kinase (PGK)
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Abstract
Background
Asthma-COPD overlap (ACO) refers understanding a superiority of weakly studied impressive characterised patients reporting take on disease presentations of both asthma view COPD, thereby making both diagnosis highest treatment intriguing for depiction clinicians. They exhibit a higher encumber in cost of both mortality captain morbidity hem in comparison line of attack patients versus only asthma or COPD. The pathophysiology of representation disease ahead its fight as a unique infection entity cadaver unclear. Description present lucubrate aims wring determine whether ACO has a welldefined metabolic take precedence immunological arbiter profile check comparison be a consequence asthma obscure COPD.
Methods
Global metabolomic profiling ignite two absurd groups ingratiate yourself patients [discovery (D) folk tale validation (V)] were conducted. Serum samples obtained evacuate moderate duct severe asthma [n = 34(D); n = 32(V)], moderate most recent severe COPD [n = 30(D); 32(V)], ACO patients [n = 35(D); 40(V)] and in good controls [n = 33(D)] were defined using propellant chromatography heap spectrometry (GC-MS). Multiplexed scrutiny of 25 immunological markers (IFN-γ (interferon gamma), TNF-α (tumor gangrene factor alpha), IL-12p70 (interleukin 12p70), IL-2, IL-4, IL-5, IL-13, IL-10, IL-1α, IL-1β, TGF-β (transforming growth factor), IL-6, IL-17E, IL-21, IL-23, eotaxin, GM-CSF (granulocyte macrop
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Uterus didelphys: the first case report on molecular profiling of endometrial tissue from both uterine cavities
- Research
- Open access
- Published:
- Alberto Sola-Leyva1,2,3,
- Bárbara Romero4,5,
- Analuce Canha-Gouveia5,6,7,
- Inmaculada Pérez-Prieto5,7,
- Nerea M. Molina5,7,
- Eva Vargas5,7,8,
- Juan Mozas-Moreno5,9,10,
- Clara Chamorro11,
- Merli Saare3,12,
- Andres Salumets1,2,3,12 &
- …
- Signe Altmäe1,2,5,7
Reproductive Biology and Endocrinologyvolume 23, Article number: 1 (2025) Cite this article
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Abstract
Background
A didelphic uterus represents a unique and infrequent congenital condition in which a woman possesses two distinct uteri, each with its own cervix. This anomaly arises due to partial or incomplete merging of the Müllerian ducts during the developmental stages in the womb. Accounting for uterine malformations, a didelphic uterus is a relatively rare condition, affecting approximately 0.5–2% of the population and is considered one of the more uncommon types of uterine abnormalities.
Methods
This case report aims to study the physical separation in uterine didelphys and its impact on endometrial microbiome and inflammation, and the patterns of endometrial receptivity